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[The future outlook of antimalarials].

Pascal Millet¹

¹TropiVal, équipe d'accueil EA 3677 Bases thérapeutiques des inflammations et des infections, Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex. pascal.millet@u-bordeaux2.fr

La Revue Du Praticien

|July 8, 2005

Summary

Chloroquine resistance dramatically impacted malaria treatment. Current strategies, including artemisinin-based therapies, aim to limit drug resistance spread while awaiting new universal antimalarial drugs.

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Area of Science:

Tropical Medicine
Infectious Diseases
Pharmacology

Context:

Chloroquine resistance emerged in the early 1960s, significantly altering global malaria treatment protocols.
Geographic variations in Plasmodium falciparum drug resistance necessitate country-specific treatment decisions.
Non-governmental organizations (NGOs) and media have increased awareness, driving antimalarial drug development.

Purpose:

To address the challenges posed by widespread antimalarial drug resistance.
To explore strategies for managing malaria treatment in the face of evolving drug resistance.
To highlight the need for novel antimalarial drug development.

Summary:

The rise of chloroquine resistance necessitated a shift in malaria treatment globally.
Multiple antimalarial drug therapies, particularly those using artemisinin derivatives, have been promoted by organizations like Médecins sans frontières and the World Health Organization.
This approach aims to curb the spread of resistance to current antimalarials while research continues for a universal treatment.

Impact:

Significant changes in global malaria treatment guidelines and drug development focus.
Increased emphasis on combination therapies to combat drug resistance.
Ongoing need for innovative antimalarial drugs to overcome resistance and provide effective worldwide treatment.

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