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Databases and software for the comparison of prokaryotic genomes
Dawn Field1, Edward J Feil2, Gareth A Wilson1
1Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK.
Microbiology (Reading, England)
|July 8, 2005
Summary
Comparative genomics, fueled by genome sequencing, needs advanced computational tools and databases. This review covers progress in developing these resources for analyzing large genome collections.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- The rapid increase in complete genome sequences has driven the growth of comparative genomics.
- Meaningful comparisons require sophisticated computational tools and accessible databases.
Purpose of the Study:
- To review the development of computational tools and databases for comparative genomics.
- To highlight progress in organizing and extracting biological insights from large genome datasets.
Main Methods:
- Review of existing literature on algorithms, databases, and software for comparative genomics.
- Analysis of the accessibility and sophistication of current computational resources.
Main Results:
- Significant progress has been made in developing computational tools for genome comparison.
- Databases are increasingly available to support the analysis of large-scale genomic data.
Conclusions:
- Further development of sophisticated and accessible computational resources is crucial for advancing comparative genomics.
- These tools are essential for unlocking the full potential of comparing large collections of genomes.