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Lansoprazole-associated collagenous colitis: a case report.
M Rammer1, A Kirchgatterer, W Höbling
11st Medical Department, Division of Gastroenterology, General Hospital Wels, Grieskirchnerstrasse 42, 4600 Wels, Austria. martin.rammer@klinikum-wels.at
Zeitschrift Fur Gastroenterologie
|July 8, 2005
Summary
Proton pump inhibitor lansoprazole may trigger collagenous colitis, a rare cause of chronic diarrhea. Stopping the medication resolved symptoms and endoscopic findings, highlighting the importance of drug review.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Microscopic colitis, including collagenous colitis, presents as chronic diarrhea with largely unknown causes.
- Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders.
Observation:
- A 57-year-old male developed chronic watery diarrhea four weeks post-Helicobacter pylori eradication therapy with lansoprazole.
- Other causes of diarrhea were excluded; endoscopy revealed a normal colon, but biopsies showed collagenous colitis.
- Discontinuation of lansoprazole resulted in rapid and lasting symptom resolution.
Findings:
- The patient's condition resolved completely after lansoprazole withdrawal, with biopsies showing no evidence of collagenous colitis two months later.
- This case suggests a potential association between lansoprazole use and the development of collagenous colitis.
Implications:
- Healthcare providers should consider medication history, particularly PPI use, in patients presenting with unexplained chronic diarrhea.
- Further research is warranted to elucidate the pathogenic mechanisms linking PPIs like lansoprazole to collagenous colitis.