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[Therapeutic approaches to non-erosive GERD--comparison between the Western countries and Japan]

Michio Hongo1, Masashi Adachi

  • 1Department of Comprehensive Medicine, Tohoku University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 9, 2005
PubMed

Insights

Patients with heartburn but no visible esophageal damage, known as non-erosive reflux disease (NERD), may experience more severe symptoms and be less responsive to treatment in Western countries compared to Japan.

Area of Science:

  • Gastroenterology
  • Reflux Esophagitis Research

Background:

  • Heartburn is a common symptom that can occur without visible esophageal damage.
  • This condition is referred to as endoscopy-negative GERD, non-erosive reflux disease (NERD), or symptomatic-GERD.
  • NERD is increasingly recognized as a distinct clinical entity.

Purpose of the Study:

  • To explore the characteristics and prevalence of non-erosive reflux disease (NERD).
  • To compare symptom severity and treatment resistance of NERD between Western countries and Japan.
  • To investigate potential factors contributing to observed differences.

Main Methods:

  • Review of clinical data and patient-reported outcomes for individuals with heartburn.
  • Comparative analysis of NERD prevalence and symptomology across different geographical regions.
  • Exploration of potential etiological factors including diet and co-occurring functional gastrointestinal disorders.

Main Results:

  • Heartburn symptoms may be more severe in patients from Europe and the United States compared to Japan.
  • Non-erosive reflux disease (NERD) patients appear more resistant to pharmacotherapy and surgical interventions.
  • NERD appears more prevalent in Western populations than in Japan.

Conclusions:

  • Geographical variations exist in the presentation and management of non-erosive reflux disease (NERD).
  • Dietary habits and the potential overlap with functional gastrointestinal disorders may contribute to these differences.
  • Further research is needed to elucidate the underlying mechanisms and optimize treatment strategies for NERD.

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