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Related Experiment Videos

Stroke-induced neurogenesis in aged brain.

Vladimer Darsalia1, Ursula Heldmann, Olle Lindvall

  • 1Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden.

Stroke
|July 9, 2005
PubMed
Summary

Stroke increases new neuron formation in aged rats, similar to young rats in the striatum. However, neurogenesis in the hippocampus is reduced in older animals, indicating age-related differences in brain repair after stroke.

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Area of Science:

  • Neuroscience
  • Aging Research
  • Stroke Recovery

Background:

  • Middle cerebral artery occlusion (MCAO) in rodents stimulates neurogenesis in young adults.
  • The impact of stroke on neurogenesis in aged brains remains less understood.

Purpose of the Study:

  • To investigate if stroke affects neurogenesis similarly in young adult and aged rodent brains.
  • To compare stroke-induced neurogenesis in the striatum and hippocampus of young versus old rats.

Main Methods:

  • Young (3-month) and old (15-month) rats underwent 1-hour MCAO.
  • New cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) for 2 weeks post-MCAO.
  • Neurogenesis was assessed at 7 weeks post-stroke using immunocytochemistry and microscopy.

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Main Results:

  • Both young and old rats showed increased striatal neurogenesis post-stroke, despite reduced basal cell proliferation in aged subventricular zones.
  • Aged rats exhibited lower numbers of stroke-generated granule cells and reduced basal neurogenesis in the dentate subgranular zone compared to young rats.
  • Impaired differentiation of new cells into neurons was observed in the aged dentate gyrus.

Conclusions:

  • Basal neurogenesis is impaired in aged animals' subgranular and subventricular zones.
  • Both brain regions in aged animals respond to stroke by increasing new neuron formation.
  • Striatal neurogenesis post-stroke is comparable in young and old rats, suggesting preserved self-repair potential in the aged brain.