ACE genotype may have an effect on single versus multiple set preferences in strength training

Area of Science:

• Exercise Physiology
• Human Genetics

Background:

• The angiotensin converting enzyme (ACE) gene has polymorphic variants.
• The 'D' variant of the ACE gene is linked to enhanced strength gains from physical training.
• Individual responses to strength training can vary.

Purpose of the Study:

• To investigate if strength training responses differ based on ACE genotype.
• To compare single-set (SSG) and multiple-set (MSG) strength training protocols.
• To determine optimal training strategies tailored to ACE gene variants.

Main Methods:

• 99 Caucasian male non-elite athletes were randomized into control (CG), SSG, or MSG groups.
• SSG and MSG groups trained for 6 weeks with 12-15 RM and 8-12 RM mesocycles.
• ACE gene polymorphisms were analyzed using PCR; strength was assessed via 1 RM loads.

Main Results:

• ACE II genotype individuals in MSG showed improved strength in 12-15 RM.
• ACE DD genotype individuals in both SSG and MSG showed similar strength gains across both RM ranges.
• ACE ID genotype individuals in SSG showed similar gains to MSG in 8-12 RM but not 12-15 RM.
• DD genotype subjects demonstrated superior strength gains in both training groups.

Conclusions:

• Strength training effectiveness may depend on ACE genotype.
• Tailoring strength training programs (single-set vs. multiple-set) to an athlete's ACE genotype could be beneficial.
• Personalized training based on genetic factors like ACE polymorphism warrants further investigation.