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Determination of nifedipine in plasma by a rapid capillary gas chromatographic method
C Le Guellec1, H Bun, M Giocanti
1Laboratoire Hospitalo-Universitaire de Pharmacocinétique et Toxicocinétique, Chu Timone, Marseille, France.
Biomedical Chromatography : BMC
|January 1, 1992
Abstract:
A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single-step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.