Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retroperitoneal soft tissue sarcoma.

William M Mendenhall1, Robert A Zlotecki, Steven N Hochwald

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610, USA. mendewil@shands.ufl.edu

Cancer
|July 9, 2005
PubMed
Summary

Optimal treatment for retroperitoneal soft tissue sarcomas (RPS) involves complete surgical resection. While adjuvant radiotherapy may reduce local recurrence, its impact on survival for advanced RPS remains uncertain.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moving beyond cancer survivorship: longevity medicine.

BMJ supportive & palliative care·2026
Same author

Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites.

Scientific reports·2026
Same author

Achieving textbook outcomes with robotic-assisted Ivor Lewis esophagectomy: a single-center experience with 150 consecutive patients.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2025
Same author

Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites.

bioRxiv : the preprint server for biology·2024
Same author

Germline Genetic Susceptibility Testing Among Emirati Nationals at Risk for Hereditary Breast and Ovarian Cancer Syndrome.

JCO global oncology·2024
Same author

Does the Surgical Approach Affect the Incidence of Post-Hepatectomy Liver Failure in Cirrhotic Patients? An Analysis of the NSQIP Database.

The American surgeon·2024

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiotherapy

Background:

  • Retroperitoneal soft tissue sarcomas (RPS) are often diagnosed at locally advanced stages.
  • Treatment strategies for RPS require optimization due to challenging surgical access and potential for recurrence.

Purpose of the Study:

  • To define the optimal treatment strategy for patients diagnosed with retroperitoneal soft tissue sarcomas.
  • To evaluate the efficacy of different treatment modalities, including surgery, radiotherapy, and chemotherapy, in managing RPS.

Main Methods:

  • A comprehensive literature review was conducted to analyze existing data on retroperitoneal soft tissue sarcomas.
  • Outcomes such as local control, distant metastasis, survival rates, and recurrence patterns were assessed.

Related Experiment Videos

Main Results:

  • Macroscopic total resection was achievable in 50-67% of patients, significantly impacting prognosis.
  • The 5-year local control rate was approximately 50%, with 20-30% developing distant metastasis.
  • Postoperative radiotherapy (RT) reduced local recurrence but did not improve survival; adjuvant chemotherapy showed no proven efficacy.

Conclusions:

  • Complete surgical resection is the cornerstone of optimal treatment for retroperitoneal soft tissue sarcomas.
  • Local recurrence is common after surgery, highlighting the need for effective adjuvant therapies.
  • Adjuvant radiotherapy may play a role in local control, but its survival benefit requires further investigation.