Approximative kinetic formats used in metabolic network modeling
Related Experiment Video
Updated: Aug 17, 2026

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
Published on: December 4, 2021
1Department of Biotechnology, Kluyver Laboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BL, Delft, The Netherlands. J.J.Heijnen@tnw.tudelft.nl
Abstract:
An overview is presented of the different approximative enzyme kinetic formats that have been proposed for use in metabolic modeling studies. It is considered that the following four general properties are relevant for approximative kinetics: the rate must be proportional to enzyme level; at high metabolite concentrations, there is downward concave behavior of rate versus concentration; the number of kinetic parameters should be as small as possible; analytical solutions of steady-state network balances are desirable. Six different approximative kinetic formats are evaluated (linear, logarithmic-linear, power law GMA, power law S-systems, thermokinetic, linear-logarithmic) and it is concluded that only the recently proposed linear-logarithmic approach combines all desired properties and therefore seems a most appropriate approximate kinetic format.
Related Concept Videos
Pharmacokinetic Models: Overview
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Reaction Mechanisms: The Steady-State Approximation
Introduction to Enzyme Kinetics
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
Model Approaches for Pharmacokinetic Data: Compartment Models
Two primary types of compartment models are recognized: mammillary and catenary. The more...

