Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metathesis reactions in total synthesis.

K C Nicolaou1, Paul G Bulger, David Sarlah

  • 1Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu

Angewandte Chemie (International Ed. in English)
|July 9, 2005
PubMed
Summary

Olefin, enyne, and alkyne metathesis reactions have revolutionized carbon-carbon bond formation and total synthesis. These powerful reactions offer novelty, elegance, and efficiency in creating complex molecules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A General Approach to <i>geminal</i>-Dimethyl <i>trans</i>-Decalin Terpenoids.

Journal of the American Chemical Society·2026
Same author

A Unified Approach for the Synthesis of Conformationally Locked and sp<sup>2</sup>-sp<sup>3</sup> Fused Hybrids.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Stereodivergent Construction of <i>trans</i>-Decalin-Based Terpenoids.

Journal of the American Chemical Society·2026
Same author

Pharmacokinetic and pharmacodynamic properties of cannabigerol in male mice.

The Journal of pharmacology and experimental therapeutics·2026
Same author

A Versatile Enzymatic Pathway for Modification of Peptide C‑Termini.

ACS central science·2025
Same author

Palladium-catalyzed dearomative 1,4-hydroamination.

Tetrahedron·2025

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Catalysis

Background:

  • Palladium-catalyzed cross-couplings are significant for carbon-carbon bond formation.
  • Metathesis reactions (olefins, enynes, alkynes) have emerged as a major transformative force in synthesis.
  • The impact of metathesis on total synthesis has been profound over the past 25 years.

Purpose of the Study:

  • To highlight key total syntheses employing metathesis reactions.
  • To showcase the novelty, elegance, and efficiency imparted by metathesis in these syntheses.
  • To underscore the growing importance of metathesis in modern chemical synthesis.

Main Methods:

  • Review of selected total synthesis examples.
  • Analysis of the role of metathesis reactions (olefin, enyne, alkyne) in these syntheses.

Related Experiment Videos

  • Evaluation of the impact on synthetic novelty, elegance, and efficiency.

    • Main Results:

    • Metathesis reactions are pivotal in numerous successful total syntheses.
    • These reactions introduce innovative strategies and streamline synthetic routes.
    • Examples demonstrate significant improvements in efficiency and molecular complexity achievable.

    Conclusions:

    • Metathesis reactions are indispensable tools in contemporary organic synthesis.
    • Their influence on the field of total synthesis continues to expand.
    • The future trajectory indicates an increasing reliance on metathesis for complex molecule construction.