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Updated: Aug 17, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
[Indications for esophageal replacement in children]
S G Aprodu1, Simona Gavrilescu, B Savu
1Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi Facultatea de Medicină, Clinica de Chirurgie şi Ortopedie Pediatrică.
Insights
Pediatric esophageal replacement surgery using colon or gastric grafts is common for atresia and strictures. Caustic ingestion was the most frequent reason for these complex esophageal substitution procedures in children.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Thoracic Surgery
Context:
- Esophageal substitution is necessary for pediatric esophageal atresia, caustic ingestion strictures, and peptic esophagitis.
- Current esophageal replacement techniques include colon segment esophagoplasty and gastric tube esophagoplasty.
- Colon segment esophagoplasty is frequently preferred by pediatric surgeons.
Purpose:
- To present personal experience in managing pediatric esophageal replacement over 10 years.
- To analyze outcomes and complications of esophageal substitution in children.
- To highlight the prevalence of caustic ingestion as an indication for esophageal replacement.
Summary:
- A series of 56 children underwent esophageal replacement.
- Indications included 46 cases of caustic ingestion, 3 of peptic esophagitis, and 7 of long-gap esophageal atresia.
- Good results were achieved in 42 cases, with 13 complications and 5 fatal outcomes.
Impact:
- This study underscores the significant role of esophageal substitution in managing severe pediatric esophageal conditions.
- The high incidence of procedures following caustic ingestion emphasizes the need for preventative measures.
- Findings contribute to understanding the outcomes of different esophageal replacement strategies in pediatric patients.
Abstract:
Esophageal substitution in children is required in several types of esophageal atresia, as well as following strictures caused by caustic ingestion or peptic esophagitis. Nowadays, two main types of procedures are used for esophageal replacement: colon segment esophagoplasty (that seems to be preferred by most pediatric surgeons) and gastric tube esophagoplasty. The paper presents the personal experience in the management of a series of 56 children with esophageal replacement, during the last 10 years. In 46 patients, the stricture cause was caustic ingestion, while peptic esophagitis accounted for 3 cases. The remaining 7 cases were long-gap esophageal atresias that could not be managed by primary neonatal anastomosis. The results are rated as good in 42 cases. Complications occurred in 13 cases, while fatal outcome occurred in 5 patients. The most remarkable feature of the series is the high number of procedures required after caustic ingestion.
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