[Antisynthetase syndrome without myositic disease: a case report]

Area of Science:

• Rheumatology
• Immunology
• Pulmonology

Background:

• Antisynthetase syndrome is a rare autoimmune disorder.
• It is classified under idiopathic inflammatory myopathies.
• Characterized by the presence of antisynthetase antibodies.

Observation:

• A patient presented with symptoms suggestive of interstitial lung disease.
• The patient also exhibited skin and articular manifestations.
• Notably, muscle involvement was absent in this case.

Findings:

• The patient tested positive for anti-Jo1 antibodies.
• This specific antibody is associated with antisynthetase syndrome.
• The clinical presentation deviated from typical myositis, lacking muscle weakness.

Implications:

• This case expands the understanding of antisynthetase syndrome's clinical spectrum.
• It emphasizes the importance of considering this syndrome even without overt muscle disease.
• Highlights the diagnostic significance of anti-Jo1 antibodies in complex autoimmune presentations.