The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and

Jennifer L Johnson1, Beverly A Ellis, Deborah Noack

  • 1Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Rab Cascades01:25

Rab Cascades

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The Ras Gene02:38

The Ras Gene

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Ras is a superfamily...
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Small GTPases - Ras and Rho

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TGF - β Signaling Pathway

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