Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging concepts in osteoporosis and bone strength.

Craig D Rubin1

  • 1Geriatric Section, University of Texas Southwestern Medical Center at Dallas, TX 75390-8889, USA. craig.rubin@utsouthwestern.edu

Current Medical Research and Opinion
|July 12, 2005
PubMed
Summary

Bone strength, crucial for preventing fractures in osteoporosis, depends on more than just bone mineral density (BMD). Bone quality factors also play a vital role in assessing fracture risk and treatment effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use and Implications of the Fracture Risk Assessment Tool in Primary Hyperparathyroidism.

JAMA network open·2026
Same author

Frailty Burden and Efficacy of Initial Invasive Strategy in Chronic Coronary Disease: The ISCHEMIA Trials.

Journal of the American Geriatrics Society·2025
Same author

Urinary incontinence in older adults - enhancing care and future research.

Current opinion in urology·2024
Same author

Androgen Deprivation Therapy Differentially Impacts Bone and Muscle in the Short Term in Physically Active Men With Prostate Cancer.

JBMR plus·2022
Same author

Pelvic muscle size and myosteatosis: Relationship with age, gender, and obesity.

The Indian journal of radiology & imaging·2019
Same author

A Team Disclosure of Error Educational Activity: Objective Outcomes.

Journal of the American Geriatrics Society·2019

Area of Science:

  • Bone biology and skeletal health.
  • Osteoporosis research.
  • Fracture risk assessment.

Background:

  • Osteoporosis is a skeletal disorder marked by reduced bone strength and increased fracture risk.
  • Bone strength is determined by bone mineral density (BMD) and bone quality (turnover, microarchitecture, mineralization, geometry).

Purpose of the Study:

  • To review the factors contributing to bone strength and osteoporosis.
  • To explore the relationship between BMD, bone quality, and fracture risk.

Main Methods:

  • MEDLINE search of English language journals (1995-2005) using terms 'osteoporosis,' 'bone strength,' and 'bone quality.'
  • Examination of reference lists from pivotal studies and reviews.
  • Overview of existing research on osteoporosis and bone strength.

Related Experiment Videos

Main Results:

  • BMD measurements reflect only one component of bone strength; fracture risk reduction is not solely explained by BMD changes.
  • Osteoporosis treatments (anti-resorptive and anabolic agents) improve bone quality (turnover, microarchitecture, mineralization) independent of or in addition to BMD.
  • Advanced imaging techniques (MRI, CT) show potential for comprehensive bone quality assessment.

Conclusions:

  • Assessing bone quality independently of BMD is essential for improving fracture risk evaluation.
  • Clinical tools for bone quality assessment are needed to advance osteoporosis treatment response monitoring.