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Neutrophils superoxide anion generation during carvedilol therapy in patients with stable angina

Jan Kowalski1, Jan Błaszczyk, Edyta Petecka

  • 1Department of Internal Medicine and Cardiological Rehabilitation, Medical University of Łódź, Poland.

International Journal of Cardiology
|July 12, 2005
PubMed

Insights

Carvedilol therapy significantly reduced neutrophil superoxide anion generation in stable angina patients. This effect normalized neutrophil function to levels seen in healthy individuals after 8-12 weeks of treatment.

Area of Science:

  • Cardiology
  • Immunology
  • Pharmacology

Background:

  • Neutrophil superoxide anion (O(2)(*-)) generation is elevated in patients with stable angina.
  • This heightened activity may contribute to the pathophysiology of the condition.

Purpose of the Study:

  • To investigate the effect of carvedilol therapy on neutrophil O(2)(*-) generation in patients with stable angina.
  • To compare neutrophil function in patients undergoing treatment with healthy controls.

Main Methods:

  • A randomized controlled study involving 27 stable angina patients treated with escalating doses of carvedilol (12.5-50 mg/day) and 12 healthy controls.
  • Neutrophil O(2)(*-) generation was measured in whole blood, both unstimulated and stimulated with opsonized zymosan (OZ), at baseline and at 4, 8, and 12 weeks post-therapy.
  • Measurements utilized the Bellavite et al. method with bovine erythrocyte superoxide dismutase.

Main Results:

  • Patients with stable angina exhibited significantly higher neutrophil O(2)(*-) generation compared to healthy controls (p<0.05).
  • Carvedilol treatment led to a statistically significant reduction in neutrophil O(2)(*-) generation by 8 and 12 weeks (p<0.05).
  • Following 8 and 12 weeks of carvedilol therapy, neutrophil O(2)(*-) generation in patients returned to levels comparable to those in healthy subjects.

Conclusions:

  • Carvedilol effectively inhibits neutrophil O(2)(*-) generation in patients suffering from stable angina.
  • The therapeutic action of carvedilol may involve the modulation of neutrophil oxidative stress, contributing to its beneficial effects in stable angina.

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