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Published on: December 9, 2022
Percutaneous ethanol injection for small hepatocellular carcinoma: therapeutic efficacy based on 20-year observation
Masaaki Ebara1, Shinichiro Okabe, Kazuhiko Kita
1Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba-shi, Chiba 260-8670, Japan. ebara@faculty.chiba-u.jp
Background/Aims:
To evaluate the therapeutic efficacy of percutaneous ethanol injection (PEI) for patients with < or = 3 lesions of small (< or = 3 cm diameter) hepatocellular carcinoma (HCC).
Methods:
PEI was applied to 270 patients with small HCC as the first-line treatment option during a 20-year period.
Results:
(1) There was no treatment-related deaths, and only 2.2% of severe complications; (2) PEI induced a complete response of all HCCs according to CT evaluation performed within one month after the procedure, and the local recurrence rate at 3 years was 10%; (3) the overall 3- and 5-year survival rates after treatment were 81.6 and 60.3%, respectively, but the rates were higher, 87.3 and 78.3%, in Child A patients with a solitary tumor < or = 2 cm in diameter; (4) factors significantly influencing survival were liver function (P = 0.0033) and serum alpha-fetoprotein level (P = 0.0014), and (5) the recurrence rate at remote sites in the liver was lower in patients with HCC < or = 2 cm (P = 0.0395) and in those with a solitary HCC (P < 0.0001) according to Cox's proportional hazard model. (6) Radiofrequency ablation would not have been performed in approximately 25% of these patients.
Conclusions:
PEI is considered a reliable treatment for small HCC in terms of safety and efficacy.
