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Updated: Aug 17, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Pathophysiology of obstructive sleep apnea
Annette G Pashayan1, Anthony N Passannante, Peter Rock
1Department of Anesthesiology, University of North Carolina School of Medicine, N2201, CB 7010, Chapel Hill, NC 27599-7010, USA. apashayan@aims.unc.edu
Abstract:
This article explores the physiologic basis and symptoms of obstructive sleep apnea--a general term encompassing central sleep apnea and obstructive sleep apnea. The former is relatively uncommon while the latter is much more common. Episodic collapse and blockage of the upper airway occur during sleep despite continuous respiratory effort. Three types of sleep obstructive breathing--apnea, hypopnea, and airway resistance--are associated with respiratory-related arousals from sleep.
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