Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple mutations contribute to repression by the v-Erb A oncoprotein.

Sangho Lee1, Martin L Privalsky

  • 1Section of Microbiology, Division of Biological Sciences, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.

Oncogene
|July 12, 2005
PubMed
Summary

Mutations in the v-Erb A oncoprotein enhance its ability to repress gene transcription by altering dimerization and corepressor binding. These changes contribute to the viral protein

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptive Time Encoding for Irregular Multivariate Time-Series Classification.

Advances in neural information processing systems·2026
Same author

Blood Pressure and Pleth Variability Index as Predictors of Tourniquet-Release Hypotension in Elderly Patients Undergoing Total Knee Arthroplasty: A Prospective Observational Study.

Life (Basel, Switzerland)·2026
Same author

Influence of Vibration Modes on CaSO<sub>4</sub> Scaling in Hollow-Fiber Membrane Distillation.

Membranes·2026
Same author

Towards Greater Representation of Diversity in Australian Dermatology Clinical Trials: Current Landscape and Strategies Forward.

The Australasian journal of dermatology·2026
Same author

Evaluation of radiation damage effects of low-energy Auger and conversion electrons emitted by <sup>134</sup>Ce decay using a Monte Carlo method.

Scientific reports·2026
Same author

Dupilumab-induced generalized pustular psoriasis in an elderly patient: a case report and literature review.

Anais brasileiros de dermatologia·2026

Area of Science:

  • Molecular Biology
  • Virology
  • Oncogenesis

Background:

  • The v-Erb A oncoprotein, derived from the c-Erb A transcription factor, possesses oncogenic properties.
  • v-Erb A functions as a constitutive transcriptional repressor, unlike its wild-type counterpart.

Purpose of the Study:

  • To analyze the specific contributions of various mutations in v-Erb A to its altered function.
  • To elucidate the molecular mechanisms underlying the oncogenic potential of v-Erb A.

Main Methods:

  • Comparative analysis of v-Erb A and c-Erb A mutations.
  • Investigation of protein dimerization, corepressor binding, and transcriptional activity.
  • Assessment of hormone-mediated regulation and target gene repression.

Related Experiment Videos

Main Results:

  • Mutations in the 'I-box' enhance v-Erb A homodimerization, corepressor binding, and gene repression.
  • A mutation in helix 3 confers thyroid hormone resistance to corepressor release.
  • C-terminal truncation allows recruitment of multiple corepressors (SMRT, N-CoR) and impairs hormone response.

Conclusions:

  • The oncogenic potential of v-Erb A is acquired through a multi-step process involving mutations that enhance its transcriptional repressive functions.
  • Altered dimerization, corepressor interactions, and hormone resistance contribute to v-Erb A's oncogenicity.