Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Development and cardiomyopathy: serum response factor, a key protein].

G Gary-Bobo1, A Huet, Z Li

  • 1Biologie moléculaire de la différenciation, université Denis-Diderot, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|July 13, 2005
PubMed
Summary

Serum response factor (SRF) plays a key role in heart function and development. Dysregulation of SRF is linked to cardiomyopathies, with inhibition causing dilated cardiomyopathy in mouse models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>TGFB1</i>, <i>FOXO1</i>, and <i>COMP</i> Genes Expression in Blood of Patients with Osteoarthritis after SARS-CoV2 Infection.

Cytology and genetics·2023
Same author

[Nasopharyngeal carriage of SARS-CoV-2 among health personnel with symptoms suggestive of COVID-19 in a University Hospital in the Paris suburbs].

La Revue de medecine interne·2020
Same author

Gender issues in cardiovascular diseases. Focus on energy metabolism.

Biochimica et biophysica acta. Molecular basis of disease·2020
Same author

Sound Coding in the Auditory Nerve: From Single Fiber Activity to Cochlear Mass Potentials in Gerbils.

Neuroscience·2018
Same author

Intermediate filaments in peripheral nervous system: Their expression, dysfunction and diseases.

Revue neurologique·2016
Same author

Computer-assisted intraosseous anaesthesia for molar and incisor hypomineralisation teeth. A preliminary study.

Odonto-stomatologie tropicale = Tropical dental journal·2015

Area of Science:

  • Molecular Biology
  • Cardiology
  • Genetics

Context:

  • Serum response factor (SRF) is a transcription factor crucial for muscle differentiation and cellular growth.
  • Recent research highlights SRF's essential role in cardiac development and function.
  • Dominant-negative SRF isoforms are implicated in various cardiomyopathies.

Purpose:

  • To review the structure, function, and role of SRF in human cardiomyopathies.
  • To discuss findings from murine models investigating SRF's function in the adult heart.
  • To explore SRF as a potential target in myocardial hypertrophy and related heart conditions.

Summary:

  • SRF is vital for cardiac development and function.
  • Altered SRF activity and isoforms are associated with cardiomyopathies.

Related Experiment Videos

  • Murine models reveal SRF inhibition leads to dilated cardiomyopathy and suggest SRF is a target of neurohumoral activation in myocardial hypertrophy.

    • Impact:

    • Provides a comprehensive overview of SRF in cardiovascular health and disease.
    • Highlights the therapeutic potential of targeting SRF in heart conditions.
    • Informs future research on SRF's role in cardiac hypertrophy and cardiomyopathy development.