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Published on: August 29, 2025
International harmonization of trial parameters in malignant lymphoma
1Competence Network Malignant Lymphoma (KML) and German Hodgkin Study Group (GHSG), University Clinics Cologne, Köln, Germany. harmonisation@biometrie.uni-koeln.de
Abstract:
Despite the publication of standardized response criteria for non-Hodgkin's lymphomas by Cheson et al., an examination of current trial parameters in nine international lymphoma study groups by the working group for quality management (WG-QM) of the Competence Network Malignant Lymphoma found differences or even missing definitions. This finding led V. Diehl, B. Cheson, and B. Pfistner to found an international project to harmonize trial parameters for malignant lymphoma. Committees of international experts on various aspects of clinical trials design and execution were formed with the charge of summarizing the current status of each aspect of trial conduct, developing a consensus as to the most current definitions, and publishing the report of those deliberations.
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