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Updated: Aug 15, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
Body plethysmography in the evaluation of intrathoracic airway abnormalities
M A Reinoso1, J R Jett, K C Beck
1Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn. 55905.
Abstract:
A patient with a previously unsuspected intrathoracic tracheal malignancy presented with symptoms suggestive of asthma and an unusual pattern seen by conventional PFTs. Reduced expiratory flows with a large difference between FVC and SVC, normal inspiratory flows and high MVV/FEV1 were found. Body plethysmography using normal and panting efforts with increasing tidal volume and flow helped define the lesion as a variable intrathoracic obstruction and document its regression after palliative therapy.
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