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Related Experiment Videos

Viscous fingering induced flow instability in multidimensional liquid chromatography.

Kirsty J Mayfield1, R Andrew Shalliker, Heather J Catchpoole

  • 1Nanoscale Organisation and Dynamics Group, University of Western Sydney, NSW, Australia.

Journal of Chromatography. A
|July 13, 2005
PubMed
Summary

Viscous fingering, a flow instability, occurs in coupled chromatography due to solvent viscosity differences. Careful solvent selection is crucial for optimal separation performance in these systems.

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Area of Science:

  • Analytical Chemistry
  • Fluid Dynamics

Background:

  • Viscous fingering is a flow instability at fluid interfaces with differing viscosities.
  • This phenomenon can impact the performance of coupled chromatographic separation systems.

Purpose of the Study:

  • To investigate the onset of viscous fingering in emulated coupled chromatographic systems.
  • To highlight the importance of solvent selection for chromatographic separation performance.

Main Methods:

  • Emulation of coupled chromatographic systems.
  • Analysis of fluid interface stability under varying solvent viscosities.

Main Results:

  • Viscous fingering was observed in emulated coupled systems.
  • Differences in solvent viscosity, such as between acetonitrile and methanol, can induce instability.

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  • Increased solvent volumes in coupled systems exacerbate viscous fingering.

    • Conclusions:

    • Viscous fingering can compromise separation efficiency in coupled chromatography.
    • Strategic solvent selection is essential to mitigate viscous fingering and ensure optimal performance.