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Up-regulation of cyclooxygenase-2 during acute human renal allograft rejection

Erika B Rangel1, Luiz A Moura, Marcello F Franco

  • 1Division of Nephrology, Hopsital do Rim e Hipertensão and Universidade Federal de São Paulo, Brazil.

Clinical Transplantation
|July 13, 2005
PubMed
Abstract

Insights

Acute renal allograft rejection shows increased cyclooxygenase-2 (COX-2) production compared to cyclooxygenase-1 (COX-1). This finding highlights COX-2

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Cyclooxygenases-1 and -2 (COX-1 and COX-2) play roles in kidney function and disease.
  • Limited information exists on COX expression during renal allograft rejection.

Purpose of the Study:

  • To analyze cyclooxygenase expression in human renal allografts during acute rejection.

Main Methods:

  • Semi-quantitative RT-PCR and immunohistochemistry were used.
  • Samples were from human renal allografts undergoing nephrectomy due to irreversible acute rejection.

Main Results:

  • COX-2 mRNA expression was significantly higher than COX-1 in acute rejection samples (p < 0.001).
  • COX-2 protein levels were elevated in interstitial cells of rejected allografts (p = 0.04).
  • COX-2 immunoreactivity was more prominent in podocytes, proximal tubules, collecting duct cells, and interstitial cells during rejection.

Conclusions:

  • Acute renal allograft rejection is associated with increased COX-2 production.

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