[Factor VII detection and its association with lipid in ischaemic heart disease]

To study the variation and significance of plasma factor VII (FVII) in various types of ischemia heart disease (IHD) and discuss its relation with plasma lipid.

FVIIa was determined with one stage clotting assay using a recombinant soluble tissue factor (rsTF). FVIIc was measured with one stage clotting assay. FVIIag was quantified with enzyme-linked immunosorbent assay (ELISA).

FVIIa in stable angina (SA), unstable angina (UA), old and acute myocardial infraction (OMI, AMI) patients were higher than that of a normal group with significant statistic differences between any two groups. FVIIag in UA, OMI and AMI were higher than that in SA and the normal group. There were positive correlations between FVIIa and serum triglycerides, FVIIa and FVIIc, FVIIc and FVIIag.

There is more or less activation of extrinsic coagulation pathway in any kind of IHD. FVIIa is the risk factor in the development of IHD and more sensitive than FVIIc or FVIIag. FVIIa is higher in OMI which may be one of the risk factors of reinfarction. Serum triglyceride may indirectly lead to the pathologic process of IHD by increasing the level of FVIIa.