Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mixed depressive syndrome].

A Koukopoulos, G Faedda, R Proietti

    L'Encephale
    |January 1, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Co-produced evidence-based recommendations for cascade screening and secondary prevention in the relatives of people diagnosed with non-syndromic thoracic aortic disease.

    Frontiers in cardiovascular medicine·2026
    Same author

    Effects of antioxidant vitamins and trace minerals on the pro-inflammatory status and liver insulin signaling pathway of transition dairy cows.

    Domestic animal endocrinology·2026
    Same author

    RSC4All as a machine learning nomogram to predict RSClin™ results in HR+/HER2- node-negative early breast cancer.

    ESMO open·2025
    Same author

    Impact of Clostridium difficile infection on stroke patients in rehabilitation wards.

    Infectious diseases now·2023
    Same author

    Splenic abscesses in childhood brucellosis: a case-based review.

    European review for medical and pharmacological sciences·2022
    Same author

    Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia.

    Archives italiennes de biologie·2021
    Same journal

    Measuring antidepressant side effects in military personnel - Clinical validation of the French version of the UKU-SERS-Pat Scale: A comparative study of patient and clinician ratings.

    L'Encephale·2026
    Same journal

    [Empowerment in addictology].

    L'Encephale·2026
    Same journal

    Evaluation of the links between smoking and conspiracy mentality.

    L'Encephale·2026
    Same journal

    Use of a relevance assessment tool in therapeutic residential care: A real world study.

    L'Encephale·2026
    Same journal

    Prevalence and characteristics of domestic violence in a sample of adult psychiatric outpatients: A cross-sectional study.

    L'Encephale·2026
    Same journal

    From representations to practice: how professionals describe supporting parents with psychiatric or somatic illness or disability.

    L'Encephale·2026
    See all related articles

    This study examined 361 patients with mood disorders, finding that certain mixed mood conditions, distinct from bipolar disorder, responded well to neuroleptics, anticonvulsants, and lithium, unlike antidepressants.

    Area of Science:

    • Psychiatry
    • Mood Disorders
    • Clinical Psychology

    Context:

    • Study conducted from April to October 1990, involving 361 manic-depressive outpatients and inpatients.
    • 178 patients presented with depression, including 45 with mixed mood disorders not meeting criteria for bipolar disorder.
    • These patients experienced severe distress with symptoms like irritability, agitation, emotional lability, and suicidal ideation.

    Purpose:

    • To investigate the characteristics and effective treatments for a specific subset of mood disorders presenting with mixed symptoms.
    • To differentiate this condition from typical depression and mixed bipolar disorder.
    • To evaluate the efficacy of various pharmacological and non-pharmacological interventions.

    Summary:

    • Patients exhibited dysphoric mood, tension, agitation, emotional lability, racing thoughts, sleep disturbances, and impulsivity.

    Related Experiment Videos

  • Antidepressants exacerbated agitation and insomnia; Benzodiazepines showed limited efficacy.
  • Neuroleptics (low dose), anticonvulsants, lithium, and electroconvulsive therapy (ECT) demonstrated significant effectiveness.

    • Impact:

    • Identifies a specific mood disorder characterized by mixed features, distinct from bipolar disorder.
    • Suggests targeted treatment strategies, highlighting the efficacy of neuroleptics, anticonvulsants, lithium, and ECT.
    • Provides insights into managing severe mood disturbances with prominent excitement components.