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Updated: Aug 17, 2026
A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
[Experimental study on anti-inflammatory and analgesic effects of Yitieling Paste]
Li-Jun Xu1, Yong-Hong Hu, Fu-Er Lu
1Institute of Integrated Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China. xulijunwxr@sina.com
Objective:
To observe the anti-inflammatory and analgesic effects of Yitieling Paste (YTLP).
Methods:
YTLP and aspirin (as a control drug) were introduced to treat the edematous ears of mice induced by xylene and swollen toes of mice induced by carrageenin, and to relieve the pain in mice induced by heat and acetic acid. The swelling degree, pain threshold and body distortions were measured.
Results:
The repression rates of the ear edema in groups of YTLP of high and low dosages and the aspirin group were 67.92%, 52.52% and 58.28%, respectively. The repression rate of the toe swelling in YTLP high dosage group was higher than that of the aspirin group, which was higher than that of the YTLP low dosage group. The results of analgesic effect of the three YTLP-treated groups showed that with the increase of dosage, the pain thresholds were higher and higher, and the body distortions were lower and lower. The pain thresholds of high and medium dosage YTLP groups were near to the aspirin group.
Conclusion:
YTLP possesses a strong anti-inflammatory and analgesic effect.