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Published on: July 29, 2019
Lindane-induced immunological alterations in human poisoning cases
Vandana Seth1, Rafat S Ahmad, Sanvidhan G Suke
1Department of Biochemistry, Environmental Biochemistry Laboratory, UCMS & G.T.B. Hospital, Dilshad Garden, Delhi-110 095, India.
Objectives:
Evaluation of immunological alterations in the blood of human lindane poisoning cases.
Design And Methods:
Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindane poisoning. The presence of lindane in blood was confirmed by HPLC.
Results:
Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered.
Conclusions:
The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.

