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A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene
Filippo Ferrara1, Francesco Meli, Corrado Amato
1Division of Angiology, University Medical Hospital, Palermo, Italy. f_ferrara@virgilio.it
Objective:
To report a case of ovarian hyperstimulation syndrome with methylenetetrahydrofolate reductase (MTHFR) gene 677T homozygosis mutation and A1298C gene heterozygosis mutation.
Design:
Case report.
Setting:
A pregnant woman in an academic hospital.
Patient(S):
A woman with ovarian hyperstimulation syndrome.
Intervention(S):
Nadroparin was administered for 2 weeks at a dosage of 200 IU/kg twice per day and then once per day; also administered once per day were folates, 5 mg; B6 vitamin, 15 mg; and B12 vitamin, 1 mg.
Main Outcome Measure(S):
Clinical follow-up.
Result(S):
Delivery was regular within the set time limits, and the fetus was born alive and in good health.
Conclusion(S):
We believe that MTHFR mutation research could be executed in women before ovarian stimulation treatment, but other observations are necessary to support this recommendation.
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