Device-related infections in children

Samir S Shah1, Michael J Smith, Theoklis E Zaoutis

  • 1Division of Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. shahs@email.chop.edu

Insights

Device-related infections require specific management, including device removal for certain bloodstream infections and all shunt infections. New antimicrobial-impregnated devices show promise in reducing infection rates.

Area of Science:

  • Infectious Diseases
  • Medical Device Technology
  • Pediatric Healthcare

Background:

  • Device-related infections pose significant challenges in healthcare settings.
  • Central venous catheters and ventriculoperitoneal shunts are common medical devices associated with infection risks.
  • Certain microorganisms, like Staphylococcus aureus and Candida spp., indicate potential disseminated infections in pediatric patients.

Purpose of the Study:

  • To summarize current management strategies for device-related infections.
  • To highlight the importance of organism identification in diagnosing disseminated infections.
  • To explore future research directions and emerging technologies for infection prevention.

Main Methods:

  • Review of management protocols for device-related infections.
  • Analysis of clinical significance of specific organism isolation.
  • Evaluation of emerging technologies like antimicrobial-impregnated devices.

Main Results:

  • Device removal is crucial for specific catheter-related bloodstream infections and all ventriculoperitoneal shunt infections.
  • Isolation of Staphylococcus aureus or Candida spp. in children with central catheters warrants investigation for disseminated infection.
  • Antimicrobial-impregnated central venous catheters and ventricular shunts demonstrate potential for reducing device-related infections.

Conclusions:

  • Effective management of device-related infections often necessitates device removal.
  • Prompt identification of specific pathogens is critical for diagnosing and managing potential disseminated infections.
  • Advancements in medical device technology, particularly antimicrobial impregnation, offer promising strategies for future infection control.

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