Metastatic testicular seminoma to the prostate

Area of Science:

• Urology
• Oncology
• Pathology

Background:

• Seminoma, a germ cell tumor, rarely involves the prostate gland.
• Primary prostatic seminoma is exceptionally rare, with only four reported cases.
• Metastasis of testicular seminoma to the prostate is also infrequently documented.

Observation:

• This report details a fourth case of testicular seminoma with metastasis to the prostate.
• The patient underwent orchiectomy and platinum-based chemotherapy for initial treatment.
• A local pelvic tumor recurrence necessitated salvage chemotherapy followed by cystoprostatectomy.

Findings:

• The described treatment regimen, including salvage chemotherapy and cystoprostatectomy with ileal neobladder, led to a disease-free outcome.
• The patient remained disease-free for 4 years post-surgery.
• This case highlights a rare presentation and successful management of advanced seminoma.

Implications:

• This case contributes to the limited literature on prostatic seminoma, offering insights into management strategies.
• The successful outcome underscores the potential efficacy of multimodal treatment including salvage chemotherapy and radical surgery.
• Further research into the optimal management of rare seminoma presentations is warranted.