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Updated: Aug 17, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Heritability of psychosis in Alzheimer disease
Silviu-Alin Bacanu1, Bernie Devlin, Kodavali V Chowdari
1Dept. of Psychiatry, Univ. of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Objective:
The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P.
Methods:
The heritability of LOAD+P, defined by single and multiple psychotic symptoms, was estimated with data from the National Institute of Mental Health AD Genetics Initiative.
Results:
The estimated heritability for LOAD+P defined by multiple psychotic symptoms was 61%; for LOAD+P defined by any occurrence of psychotic symptoms, it was 30%.
Conclusion:
Multiplicity of symptoms may represent a useful means for defining a genetically determined LOAD+P phenotype.
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