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Published on: January 27, 2015
Moyamoya syndrome with intraventricular hemorrhage in an adult with factor V Leiden mutation
Rosette Jabbour1, Ali Taher, Ali Shamseddine
1Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. rj04@aub.edu.lb
Objective:
To report a case of proximal occlusion of 2 major cerebral vessels associated with moyamoya network circulation that manifested by spontaneous intraventricular hemorrhage.
Design:
Case report.
Patient And Results:
A 36-year-old Syrian man presented with symptoms of sudden-onset headache, neck stiffness, and confusion. The computed tomography scan of his brain showed intraventricular bleeding, and the subsequent 4 vessel angiographies revealed occlusion of the left middle and anterior cerebral arteries with moyamoya appearance in the terminal branches. The coagulation profile showed the presence of heterozygous factor V Leiden mutation. The patient was treated conservatively until resolution of his blood clot, and later he was started on oral anticoagulation.
Conclusion:
Factor V Leiden mutation may cause large cerebral vessel occlusion with moyamoya syndrome in adults.
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