Related Experiment Video
Updated: Aug 17, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
The International Classification of Retinopathy of Prematurity revisited
Insights
The revised International Classification of Retinopathy of Prematurity (ICROP) offers a more quantitative approach to diagnosing retinopathy of prematurity. Key updates include aggressive posterior retinopathy of prematurity and pre-plus disease.
Area of Science:
- Ophthalmology
- Neonatology
Background:
- The International Classification of Retinopathy of Prematurity (ICROP) has been instrumental in advancing research and understanding of this condition.
- Improved imaging technologies necessitate a refined classification system for retinopathy of prematurity.
Framework:
- A revised ICROP classification has been developed by an international consensus of pediatric ophthalmologists and retinal specialists.
- The updated framework introduces the concept of aggressive posterior retinopathy of prematurity (ROP) in premature infants.
- It also defines an intermediate stage of vascular changes, termed 'pre-plus' disease, and provides a tool for estimating Zone I extent.
Implementation:
- The revised classification aims to enhance the quantitative assessment of retinopathy of prematurity characteristics.
- It provides a more precise tool for clinical evaluation and research in neonatal eye care.
Implications:
- The updated ICROP facilitates more accurate diagnosis and potentially improved treatment strategies for retinopathy of prematurity.
- This revision supports ongoing research and clinical trials for this potentially blinding condition in premature infants.
Abstract:
The International Classification of Retinopathy of Prematurity (ICROP) was published in 2 parts, the first in 1984 and later expanded in 1987. It was a consensus statement of an international group of retinopathy of prematurity experts. The original classification has facilitated the development of large multicenter clinical treatment trials and furthered our understanding of this potentially blinding disorder. With improved imaging techniques in the nursery, we are able to offer a more quantitative approach to some of the characteristics described in the ICROP. An international group of pediatric ophthalmologists and retinal specialists has developed a consensus document that revises some aspects of ICROP. Few modifications were felt to be needed. The aspects that differ from the original classification include introduction of (1) the concept of a more virulent form of retinopathy observed in the tiniest babies (aggressive, posterior ROP), (2) a description of an intermediate level of plus disease (pre-plus) between normal posterior pole vessels and frank plus disease, and (3) a practical clinical tool for estimating the extent of zone I.
Related Concept Videos
Diabetic Retinopathy
The Retina

