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High sensitivity measurement of CRP and disease progression in multiple sclerosis
M Soilu-Hänninen1, J O Koskinen, M Laaksonen
1Department of Neurology, Institute of Biomedicine, University of Turku, Finland. mersoi@utu.fi
Abstract:
The authors measured serum C-reactive protein (CRP) serially in patients with multiple sclerosis (MS) who participated the PRISMS study using a high-sensitivity technique. CRP values were similar in patients with MS and in healthy controls but higher during MS relapses than in remission (p = 0.010). CRP levels were lower during treatment with high-dose interferon beta 1a than placebo (p = 0.035) and higher during first 12 months of study in patients who progressed by year 4 compared with stable patients (p = 0.007).
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