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Prognostic clinical variables in childhood tuberculous meningitis: an experience from Mumbai, India

Sunil Karande1, Vishal Gupta, Madhuri Kulkarni

  • 1Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. karandesunil@yahoo.com

Neurology India
|July 13, 2005
PubMed

Insights

Tuberculous meningitis (TBM) in children poses significant risks. Hypertonia predicts long-term disability in survivors, while deep coma indicates a higher mortality risk in TBM patients.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Tuberculous meningitis (TBM) remains a critical cause of mortality and neurological impairment in children in India.
  • Early identification of prognostic factors is crucial for managing childhood TBM.

Purpose of the Study:

  • To determine clinical variables that predict outcomes in pediatric tuberculous meningitis.
  • To identify predictors of survival with disability and mortality in childhood TBM.

Main Methods:

  • A prospective observational study was conducted at a tertiary teaching hospital.
  • 123 children with TBM were analyzed for 36 clinical variables.
  • Outcomes were assessed as complete recovery, survival with disability, or death.

Main Results:

  • 20% of children recovered fully, 57% survived with disability, and 23% died.
  • Nine variables correlated with survival with disability, including neurological deficits and hydrocephalus.
  • Deep coma was associated with both survival with disability and fatal outcomes.

Conclusions:

  • Hypertonia at admission independently predicts neurological sequelae in surviving children with TBM.
  • Deep coma is an independent predictor of mortality in pediatric TBM cases.
Abstract

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