Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative genomics on BMP4 orthologs.

Yuriko Katoh1, Masaru Katoh

  • 1M&M Medical BioInformatics, Hongo 113-0033, Japan.

International Journal of Oncology
|July 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody-drug conjugates targeting the cadherin, claudin and nectin families of adhesion molecules.

Frontiers in molecular medicine·2025
Same author

Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review).

International journal of molecular medicine·2024
Same author

Grand Challenges in Molecular Medicine for Disease Prevention and Treatment Through Cyclical Innovation.

Frontiers in molecular medicine·2024
Same author

Monoclonal antibodies that target fibroblast growth factor receptor 2 isoform b and Claudin-18 isoform 2 splicing variants in gastric cancer and other solid tumours.

Clinical and translational medicine·2024
Same author

FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions.

Nature reviews. Clinical oncology·2024
Same author

Activated FGFR2 signalling as a biomarker for selection of intrahepatic cholangiocarcinoma patients candidate to FGFR targeted therapies.

Scientific reports·2024

Bone morphogenetic protein 4 (BMP4) orthologs were identified across vertebrates using bioinformatics. Key promoter regions and binding sites show conservation, suggesting functional importance in gene regulation.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Bone morphogenetic proteins (BMPs) play crucial roles in cell-fate determination in embryonic stem cells and cancer cells.
  • BMP4 is notably expressed in diffuse-type gastric cancer cells.
  • GREM1 and CER1 are secreted antagonists of BMP signaling.

Purpose of the Study:

  • To identify and characterize vertebrate Bone morphogenetic protein 4 (BMP4) orthologs.
  • To analyze comparative proteomics and genomics of BMP4 across species.
  • To investigate the conservation of BMP4 gene structure and promoter regions.

Main Methods:

  • Bioinformatic analysis was employed to identify and characterize BMP4 orthologs.
  • Comparative proteomics and comparative genomics were utilized for analysis.

Related Experiment Videos

  • Gene structure, exon-intron organization, and promoter regions were examined.

    • Main Results:

    • Vertebrate BMP4 orthologs were identified in baboon, cow, bat, mouse, rat, chicken, and zebrafish.
    • High amino acid identity was observed between human BMP4 and its orthologs, with notable variations in baboon BMP4.
    • The 5'-flanking region of exon 1 and exon 1 itself are conserved in human and rodent BMP4, containing conserved transcription factor binding sites (FOXA2, OLF1, MYC).

    Conclusions:

    • Bioinformatic identification and characterization of BMP4 orthologs reveal significant conservation across vertebrates.
    • Conserved promoter regions and transcription factor binding sites suggest a conserved regulatory mechanism for BMP4.
    • These findings provide insights into the evolutionary and functional aspects of BMP4 in various species.