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Felbamate reduces hypoxic-ischemic brain damage in vivo
C G Wasterlain1, L M Adams, H Hattori
1Epilepsy Research Laboratory, VA Medical Center, Sepulveda, CA 91343.
European Journal of Pharmacology
|March 3, 1992
Abstract:
The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.