Related Experiment Video

Updated: Aug 1, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

[Urinary retention in 2 children after the use of antiemetic agents during acute gastroenteritis]

R A de Moor1, W L Diemont, M O J M Visser

  • 1TweeSteden Ziekenhuis, afd. Kindergeneeskunde, Postbus 90.107, 5000 LA Tilburg. rdmoor@tsz.nl

Nederlands Tijdschrift Voor Geneeskunde
|July 14, 2005
PubMed

Insights

Domperidone and metoclopramide, anti-dopaminergic antiemetic drugs, can cause urinary retention in young children. Careful prescribing is essential to prevent adverse events in pediatric patients.

Area of Science:

  • Pediatric Pharmacology
  • Gastroenterology
  • Clinical Toxicology

Background:

  • Acute gastroenteritis and vomiting are common pediatric conditions.
  • Domperidone and metoclopramide are anti-emetic medications frequently used in children.
  • Anti-dopaminergic agents carry potential risks, especially in younger populations.

Observation:

  • Two pediatric patients, aged 2 and 4 years, presented with acute gastroenteritis and vomiting.
  • One child received domperidone, and the other received metoclopramide for symptom management.
  • Both children subsequently developed urinary retention as an adverse effect.

Findings:

  • Urinary retention resolved in both cases after a single bladder catheterization and discontinuation of the anti-emetic medication.
  • No long-term complications were observed in the children following the adverse event.
  • This suggests a direct link between the anti-dopaminergic antiemetics and the observed urinary retention.

Implications:

  • Clinicians should exercise caution when prescribing domperidone and metoclopramide to young children.
  • Awareness of potential urinary retention as an adverse effect is crucial for pediatric healthcare providers.
  • Further research into the specific mechanisms and risk factors for this side effect in children is warranted.

More Related Videos

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting05:33

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Published on: August 4, 2023

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Nursing Assessment of the Genitourinary System II: Inspection and Palpation01:26

Nursing Assessment of the Genitourinary System II: Inspection and Palpation

The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...