[Inclusion constant of beta-CD and paeonol measured by phase solubility method]
Xue-fen Wu1, Xiao-ke Zheng, Hong-jian Yao
1Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China. wxf@hactcm.edu.cn
Objective:
Measure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol,
Method:
The thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method.
Result:
Comparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1).
Conclusion:
Inclusion constant is applied to research the stability of included drug in physiological condition.
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