Related Experiment Video
Updated: Aug 9, 2026
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
Published on: June 11, 2017
[Ameliorative effect of ginseng glycopeptide on cross-linking of rat tail tendon collagen]
Cai Li1, Xiang-jun Li, Chun-sheng Miao
1Institute of Frontier Medical Science, Jilin University, Changchun 130021, China. licaijia@public.cc.jl.cn
Objective:
To investigate the ameliorative effect of ginseng glycopeptide on cross-linking of rat tail tendon collagen.
Method:
ELISA was used to determine the inhibitory effect of ginseng glycopeptide on cross-linking of rat tail tendon collagen in vitro. After ginseng glycopeptide was intraperitoneally administrated to streptozotocin-induced diabetic rats for 12 weeks, the acid solubility, limited pepsin degradation properties and solubility in SDS-2-mercaptoethanol of the rat tail tendon collagen were determined, and the effect of ginseng glycopeptide on the tail tendon collagen cross-linking was evaluated.
Result:
Ginseng glycopeptide inhibited significantly the cross-linking of rat tail tendon collagen in vitro. The solubility of the tail tendon collagen (in acid, pepsin and SDS-2-mercaptoethanol) was markedly decreased in diabetic rats and ginseng glycopeptide-treated diabetic rats had significantly an increase in the collagen solubility in the above-mentioned solutions, suggesting that ginseng glycopeptide decreased severity of the collagen cross-linking.
Conclusion:
Ginsengglycopeptide exhibits an significantly ameliorative effect on cross-linking of rat tail tendon collagen.
