Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antidepressant amides from Piper laetispicum C. DC].

Sheng-li Pan1, Jing Xie, Fu-gang Qian

  • 1School of Pharmacy, Fudan University, Shanghai 200032, China. panshengli@online.sh.cn

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|July 14, 2005
PubMed
Summary

Researchers identified three amide compounds from Piper laetispicum C. DC. One novel compound, laetispicine, and two other amides showed potential antidepressant activity in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis.

Oncotarget·2016
Same author

Local versus general anaesthesia for adults undergoing pars plana vitrectomy surgery.

The Cochrane database of systematic reviews·2016
Same author

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.

ACS infectious diseases·2016
Same author

Effect of nonylphenol on volatile fatty acids accumulation during anaerobic fermentation of waste activated sludge.

Water research·2016
Same author

Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide.

ACS applied materials & interfaces·2016
Same author

Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.

PloS one·2016

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Context:

  • Piper laetispicum C. DC. is a plant species with potential medicinal properties.
  • Natural products are a rich source of novel therapeutic agents.
  • Identifying plant-derived compounds with biological activity is crucial for drug discovery.

Purpose:

  • To isolate and characterize antidepressant constituents from Piper laetispicum C. DC.
  • To evaluate the antidepressant activity of isolated compounds using the mouse forced swimming test.

Summary:

  • Three amide compounds were isolated from Piper laetispicum C. DC. using column chromatography.
  • Their structures were elucidated through comprehensive spectroscopic analyses (MS, HR-MS, UV, IR, 1D- and 2D-NMR).
  • The isolated compounds are N-isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E, 4E-nonadienamide (II), and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III).

Related Experiment Videos

Impact:

  • Compound (I) is a new chemical entity named laetispicine.
  • Compounds (II) and (III) were identified as natural products for the first time.
  • This study contributes to understanding the phytochemistry of Piper laetispicum and provides potential leads for antidepressant drug development.