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Digit ratio (2D:4D) and behavioral differences between inbred mouse strains.

A A Bailey1, D Wahlsten, P L Hurd

  • 1Department of Psychology, University of Alberta, Edmonton, Alberta, Canada.

Genes, Brain, and Behavior
|July 14, 2005
PubMed
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Digit ratio (2D:4D) shows sex differences across species. Inbred mice exhibit significant variations in hind paw digit ratios, making them a valuable model for studying digit ratio and behavior correlations.

Area of Science:

  • Comparative anatomy
  • Behavioral genetics
  • Endocrinology

Background:

  • Digit ratio (2D:4D) is a sexually differentiated trait observed in humans and other species.
  • Lower 2D:4D ratios in humans are associated with higher prenatal androgen exposure and linked to traits like athletic ability and aggression.
  • Similar sex-based patterns in 2D:4D have been noted in the hind paws of laboratory mice.

Purpose of the Study:

  • To investigate digit ratio (2D:4D) variations across different inbred mouse strains.
  • To determine if inbred mice are a suitable model for exploring the relationship between digit ratio and behavioral traits.

Main Methods:

  • Hind paw digit ratios (2D:4D) were measured in mice from eight inbred strains.
  • Measurements were conducted blind to strain, sex, and paw laterality.

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Main Results:

  • Significant differences in hind paw digit ratio were observed among the eight inbred mouse strains.
  • The study confirmed the sexually differentiated pattern of 2D:4D in mice, with males generally exhibiting lower ratios.

Conclusions:

  • Inbred mouse strains display substantial variability in digit ratio.
  • Inbred mice represent a promising model system for future research into the correlations between digit ratio and various behavioral phenotypes.