Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microhardness changes in dentine after neonatal capsaicin application.

T L Krage1, A Stiefel, B M Stephan

  • 1Department of Operative and Preventive Dentistry and Endodontics, Heinrich-Heine University, Duesseldorf, Germany. krage@med.uni-duesseldorf.de

International Endodontic Journal
|July 14, 2005
PubMed
Summary

Eliminating nerve signals in rat dental pulp with capsaicin reduced dentine quality. This suggests nociceptive innervation impacts odontoblast function and dentine formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epithelial Rests of Malassez Form a Wnt-Dependent Mechanoresponsive Network.

Journal of dental research·2026
Same author

Injury-Activated ERMs Undergo EMT and May Contribute to Periodontal Repair.

Journal of dental research·2025
Same author

Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.

Basic research in cardiology·2025
Same author

The impact of preexisting omega-3 fatty acid serum levels on outcomes following out-of-hospital cardiac arrest: A comprehensive investigation.

Life sciences·2025
Same author

The interplay between COVID-19 and heart disease: Unravelling a complex connection.

Life sciences·2025
Same author

Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.

Frontiers in cardiovascular medicine·2023

Area of Science:

  • Dental Research
  • Neuroscience
  • Developmental Biology

Background:

  • Odontoblasts are crucial for dentine formation and maintenance.
  • Dental pulp contains nociceptive nerve fibers that may influence odontoblast activity.

Purpose of the Study:

  • To investigate the effect of eliminating nociceptive innervation on odontoblast function in rats.
  • To assess changes in dentine quality following neonatal capsaicin treatment.

Main Methods:

  • Neonatal capsaicin administration to desensitize nociceptive pulp innervation.
  • Vicker's microhardness testing on incisor dentine at 150 days.
  • Immunohistological confirmation of CGRP desensitization.

Main Results:

Related Experiment Videos

  • Dentine microhardness was significantly lower in capsaicin-treated rats compared to controls (P < 0.001).
  • This indicates reduced dentine quality following nociceptive nerve elimination.

    • Conclusions:

    • Neonatal capsaicin treatment alters dentine quality in rats.
    • Selective elimination of nociceptive innervation in dental pulp affects odontoblast function.