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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Detection of Candida species in vaginal samples in a clinical laboratory setting
Jason P Trama1, Martin E Adelson, Israel Raphaelli
1Medical Diagnostic Laboratories, L.L.C, Hamilton, NJ 08690, USA.
Objective:
To present the detection rates of Candida species in vaginal samples from patients visiting physicians.
Methods:
The presence of C. albicans, C. glabrata, C. parapsilosis and C. tropicalis in 3978 vaginal swabs from patients in six US states was detected by PCR amplification.
Results:
Candida DNA was detected in 33.1% of the population studied. Of the 1316 positive samples, 80.2% contained C. albicans, 14.3% contained C. glabrata, 5.9% contained C. parapsilosis and 8.0% contained C. tropicalis. Comparing samples by patients' state of residence revealed an association with the detection of C. glabrata (p = 0.029). Comparing samples by patients' age revealed a decrease in the overall detection of Candida (p < 0.001) and C. albicans (p < 0.001), concomitant with an increase in the detection of C. glabrata (p < 0.001) and C. parapsilosis (p = 0.025).
Conclusions:
These results provide geographic- and age-specific data on four Candida species associated with vaginitis.
