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Updated: Feb 20, 2026
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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
Published on: September 27, 2019
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Tissue engineering
1Division of Otolaryngology, Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0293, USA. oaaros2@uky.edu
Summary
Regenerative medicine and tissue engineering offer hope for damaged tissues, but clinical application is limited. Further research into cell biology and tissue development is crucial for advancing these regenerative therapies.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Regenerative Medicine
Background:
- Regenerative medicine aims to restore damaged tissues and organs.
- Tissue engineering integrates cell biology and biomedical engineering for tissue design.
- Clinical translation of tissue regeneration remains limited despite progress.
Purpose of the Study:
- Review current understanding and advances in regenerative medicine.
- Identify limitations in current tissue engineering techniques.
- Discuss future development areas in tissue regeneration.
Main Methods:
- Review of extracorporeal and in-vitro tissue engineering approaches.
- Discussion of tissue engineering principles: scaffolds, stem cells, patterning, microcirculation, and stimuli.
- Analysis of current state-of-the-art in skin, cartilage, bone, adipose, and neural tissue regeneration.
Main Results:
- Key tissue engineering principles include bioactive scaffolds, progenitor/stem cells, patterning, and microcirculation.
- External stimuli are important for cell differentiation in tissue engineering.
- Significant knowledge gaps exist in progenitor cell biology, cell interactions, and differentiation cues.
Conclusions:
- Current limitations in regenerative medicine highlight research opportunities.
- Gaps in understanding cellular biology and tissue development need addressing.
- Further research is essential for advancing tissue engineering and clinical applications.
