Three cases of diffuse large B-cell lymphoma of the mandible treated with radiotherapy and chemotherapy
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Masanori Someya1, Koh-Ichi Sakata, Hisayasu Nagakura
1Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Hokakaido, Japan.
Case Report:
We report three cases of diffuse large B-cell lymphoma of the mandible and a review of the literature. All 3 of our patients had stage I AE disease and had complete remission for more than 2 years after 42-46 Gy of irradiation to the primary tumor with regional lymph nodes and 3 courses of chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, and predonisolone (CHOP). Literature analysis, although biased toward published data, indicated that the 3-year disease-specific survival rates for non-Hodgkin's lymphoma (NHL) of the mandible were 90.5% and 47.6% for stages I and II, respectively. The treatment results for NHL of the mandible may be similar to general primary bone NHL and to other extranodal NHL's.
Conclusion:
Radiotherapy alone is not sufficient for tumor control for stage I+II, disease, and combination chemotherapy may be needed.