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Related Experiment Videos

Scleroderma associated with ANCA-associated vasculitis.

Young Hee Rho1, Seong Jae Choi, Young Ho Lee

  • 1Division of Rheumatology, Korea University Anam Hospital, 126-1, 5-ka Anam-dong, Seongbuk-Ku, Seoul, Korea, 136-705.

Rheumatology International
|July 14, 2005
PubMed
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Scleroderma and ANCA-associated vasculitis (AAV) rarely coexist. This report details two Korean scleroderma cases with concurrent AAV, emphasizing timely diagnosis for effective treatment and remission.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Scleroderma and ANCA-associated vasculitis (AAV) are distinct autoimmune diseases.
  • Coexistence of scleroderma and AAV is uncommon, posing diagnostic challenges.

Observation:

  • Two Korean patients with limited scleroderma and pulmonary fibrosis were identified.
  • These patients presented with ANCA-positivity and clinical signs of vasculitis.

Findings:

  • Both patients received high-dose steroids and cyclophosphamide, achieving remission.
  • The cases highlight the importance of considering AAV in scleroderma patients with atypical inflammatory features.

Implications:

  • Early recognition of AAV in scleroderma patients is crucial for prompt and effective management.

Related Experiment Videos

  • This finding may influence diagnostic algorithms for scleroderma patients presenting with unusual inflammatory symptoms, particularly renal involvement.