Related Experiment Video
Updated: Aug 17, 2026

Whole-Kidney Three-Dimensional Staining with CUBIC
Published on: July 18, 2022
Histopathological atlas of renal diseases: ANCA-associated vasculitis (Second part)
Franco Ferrario1, Maria Pia Rastaldi
1Renal Immunopathology Center, S. Carlo Borromeo Hospital, Milan, Italy. franco.ferrario@oscb.sined.net
Abstract:
In the first part of Histopathological Atlas of Renal Diseases we described the typical morphological features of Anca-associated vasculitis. The histological features in Wegener's granulomatosis, Micropolyarteritis and its renal-limited variant, are characterized by "pauci immune" necrotizing extracapillary glomerulonephritis. The cellular composition of glomerular crescent and the mechanisms underlying crescent formation are still incompletely understood. The recent availability of monoclonal antibodies directed against epithelial cells and leucocytes allowed a more precise identification of the crescent cells. In this chapter we will describe the prevalent presence of monocytes in the crescents, the possible mechanisms of recruitment of these cells and the morphological consequences of this glomerular infiltration for the chronic progression of lesions.
Related Concept Videos
Imaging Studies VII: Vascular Imaging
Acute Kidney Injury II: Pathophysiology
Anatomy of the Genitourinary System I: Kidneys and Ureters
Imaging Studies II: Ultrasonography
External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Blood and Nerve Supply to the Kidney
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
