Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Posthypoxic changes in the metabolism of the developing brain].

T P Zhukova, E G Sorokina, Iu G Popandopulo

    Voprosy Meditsinskoi Khimii
    |November 1, 1979
    PubMed
    Summary

    Intranatal hypoxia significantly impacts developing rat brains, altering energy metabolism and amino acid levels. These changes suggest irreversible brain damage, highlighting the critical effects of oxygen deprivation during development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain-Intestine Axis.

    Biophysics·2023
    Same author

    Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine.

    Biophysics·2022
    Same author

    [APOΕ gene polymorphism and markers of brain damage in the outcomes of severe traumatic brain injury in children].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2020
    Same author

    Chitosan-g-oligo(L,L-lactide) copolymer hydrogel for nervous tissue regeneration in glutamate excitotoxicity: in vitro feasibility evaluation.

    Biomedical materials (Bristol, England)·2019
    Same author

    [Peripheral Blood Lymphocytes Mitochondrial Function in Children with Traumatic Brain Injury].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2016
    Same author

    [Biomarkers in children with traumatic brain injury].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2015

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Developmental Biology

    Background:

    • Intranatal hypoxia poses a significant risk to brain development.
    • Understanding the biochemical sequelae of hypoxia is crucial for assessing neurological outcomes.

    Purpose of the Study:

    • To investigate the long-term effects of intranatal hypoxia on brain biochemistry in developing rats.
    • To analyze changes in energy metabolism and amino acid profiles following hypoxia.

    Main Methods:

    • Biochemical analysis of rat brain tissue at various postnatal stages (1 day to 5 months).
    • Measurement of adenylic nucleotides, glycogen, lactic acid, ATP-ase activity, and free amino acids.

    Main Results:

    • Acute hypoxia decreased adenylic nucleotides and glycogen, increased lactic acid, and reduced ATP-ase activity.
    • Posthypoxic periods showed altered energy metabolism and shifts in essential vs. nonessential amino acids.
    • Later stages (1.5-2 months) revealed decreased macroergic compounds and impaired ATP-ase activity.

    Conclusions:

    • Intranatal hypoxia induces significant biochemical alterations in the developing brain.
    • The observed biochemical changes suggest a basis for irreversible neurological impairments.
    • Hypoxia disrupts critical developmental processes, impacting energy homeostasis and protein synthesis.

    Related Experiment Videos