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Updated: Aug 17, 2026
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An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
[The system design of an intraperitoneal perfusion machine for hyperthermic chemotherapy based on single chip
Zhiyong Zhang1, Xuandong Yang, Kaiyang Li
1Physical Science and Technology Institute of Wuhan University, Wulhan 430072, China.
Summary
A novel intraperitoneal hyperthermic chemotherapy method shows high effectiveness for gastrointestinal cancer. This study details a perfusion machine that precisely controls chemotherapy drug temperature for optimal treatment delivery.
Area of Science:
- Oncology
- Medical Engineering
- Chemotherapy Delivery Systems
Background:
- Gastrointestinal cancers present significant treatment challenges.
- Intraperitoneal hyperthermic chemotherapy (IPHC) is an emerging therapeutic strategy.
- Optimizing drug delivery and temperature control is crucial for IPHC efficacy.
Purpose of the Study:
- To introduce a novel intraperitoneal perfusion machine for IPHC.
- To demonstrate the machine's capability in precise temperature regulation of chemotherapy drugs.
- To highlight the potential of this method in treating gastrointestinal cancers.
Main Methods:
- Development of a specialized intraperitoneal perfusion machine.
- Integration of a heating system to warm chemotherapy solutions.
- Utilization of a microcontroller unit (MCU) for precise control of heating temperature and flow rate.
- Infusion of heated chemotherapy liquor into the abdominal cavity, with subsequent outflow and discarding.
Main Results:
- The developed machine effectively heats and delivers chemotherapy drugs intraperitoneally.
- Precise control over drug temperature within the abdominal cavity was achieved.
- The system allows for adjustment to the most favorable therapeutic temperature.
Conclusions:
- The reported intraperitoneal perfusion machine is effective for IPHC in gastrointestinal cancer therapy.
- Precise temperature control enhances the potential efficacy of chemotherapy.
- This technology offers a promising advancement in localized cancer treatment.
